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ChemicalBook >> CAS DataBase List >>Triphenylphosphine


Chemical Name:
PPh3;Triphenylphosphane;Triphenyl phosphine;Triphenyl;Triphenyphosphine;triphenyl-phosphane;TRIPHENYLPHOSPHORUS;LPO Assay Triphenylphosphine;PP-360;'LGC' (4006)
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2023-10-07 17:44:49

Triphenylphosphine Properties

Melting point 79-81 °C(lit.)
Boiling point 377 °C(lit.)
Density 1.132
vapor density 9 (vs air)
vapor pressure 5 mm Hg ( 20 °C)
refractive index 1.6358
Flash point 181 °C
storage temp. Store below +30°C.
solubility water: soluble0.00017 g/L at 22°C
form Crystals, Crystalline Powder or Flakes
Specific Gravity 1.132
color White
Odor odorless
Water Solubility Insoluble
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Merck 14,9743
BRN 610776
Stability Stable. Incompatible with oxidizing agents, acids.
CAS DataBase Reference 603-35-0(CAS DataBase Reference)
NIST Chemistry Reference Phosphine, triphenyl-(603-35-0)
EPA Substance Registry System Triphenylphosphine (603-35-0)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H302-H317-H318-H372
Precautionary statements  P260-P280-P301+P312-P302+P352-P305+P351+P338-P314
Hazard Codes  Xn,N
Risk Statements  22-43-53-50/53-48/20/22
Safety Statements  36/37-60-61-36/37/39-26
RIDADR  3077
WGK Germany  2
RTECS  SZ3500000
Autoignition Temperature 425 °C
HS Code  29310095
Toxicity LD50 orally in Rabbit: 700 mg/kg LD50 dermal Rabbit > 4000 mg/kg
NFPA 704
2 0

Triphenylphosphine price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T84409 Triphenylphosphine ReagentPlus , 99% 603-35-0 1g $30.9 2023-06-20 Buy
Sigma-Aldrich T84409 Triphenylphosphine ReagentPlus , 99% 603-35-0 1kg $199 2023-06-20 Buy
Sigma-Aldrich 8.08270 Triphenylphosphine for synthesis 603-35-0 5G $29.9 2023-06-20 Buy
Sigma-Aldrich 8.08270 Triphenylphosphine for synthesis 603-35-0 250g $82.6 2023-06-20 Buy
Sigma-Aldrich 93092 Triphenylphosphine ≥95.0% (GC) 603-35-0 1kg $194 2023-06-20 Buy
Product number Packaging Price Buy
T84409 1g $30.9 Buy
T84409 1kg $199 Buy
8.08270 5G $29.9 Buy
8.08270 250g $82.6 Buy
93092 1kg $194 Buy

Triphenylphosphine Chemical Properties,Uses,Production


Triphenylphosphine (TPP) is an important ligand, and is also utilized in the Wittig reaction for alkene synthesis. This reaction involves the formation of alkyliden-etriphenylphosphoranes from the action of butyllithium or other base on the quarternary halide.
Triphenylphosphine is used in the synthesis of organic compounds due to its nucleophilicity and its reducing character. TPP is a highly efficient product that serves successfully in many applications, for example:
The important ligands of homogeneous catalysts used in petrochemicals and fine chemicals production, as a co-catalyst in isobutanol and n-butanol production.
The basic raw material of rhodium phosphine complex catalyst, It is used to prepare Wilkinson's catalyst, RhCl(PPh3)3 useful to catalyze the hydrogenation of alkenes and tetrakis(triphenylphosphine)palladium(0) that is widely used to catalyze C-C coupling reactions in organic synthesis.
In the dye industry, Triphenylphosphine is used as sensitizer, heat stabilizers, light stabilizers, antioxidants, flame retardants, antistatic agents, rubber antiozonants and analytical reagent.

Chemical properties

Triphenylphosphine is a common organophosphorus compound with the formula P(C6H5)3 - often abbreviated to PPh3 or Ph3P. It is widely used in the synthesis of organic and organometallic compounds. PPh3 exists as relatively air stable, colorless to pale yellow monoclinic crystals at room temperature. It is a colorless to pale yellow transparent oily liquid above the room temperature with skin irritation and a pungent odour. It dissolves in non-polar organic solvents such as benzene and diethyl ether.

Name Reactions

  1. Mitsunobu reactions
    The triphenylphosphine combines with DEAD to generate a phosphonium intermediate that binds to the alcohol oxygen, activating it as a leaving group. Substitution by the carboxylate, mercaptyl, or other nucleophile completes the process.
  2. Ozonolysis reactions
    Ozonolysis allows the cleavage of alkene double bonds by reaction with ozone. Depending on the work up, different products may be isolated: reductive work-up gives either alcohols or carbonyl compounds, while oxidative work-up leads to carboxylic acids or ketones.
  3. Staudinger reactions
    Triphenylphosphine reacts with the azide to generate a phosphazide, which loses N2 to form an iminophosphorane. Aqueous work up leads to the amine and the very stable phosphine oxide.
  4. Appel reactions
    The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.
    This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.
Name Reactions (Mitsunobu Ozonolysis  Staudinger Appel reactions)


Triphenylphosphine is first sulfonated with oleum to form the trisulfonic acid.
Triphenylphosphine can be used in Wittig synthesis. It is a standard ligand in homogeneous catalysis.
Triphenylphosphine is used in the synthesis of an organophosphorus intermediate, trimethyl phosphite in ester exchange method. And then a series of organophosphorus pesticides such as dichlorvos, monocrotophos and phosphamidon can be further obtained.
In addition, it can be used as stabilizers in the synthesis of rubber and resins, antioxidants in polyvinyl chloride, and raw material in the synthesis of alkyd resins and polyester resins.

Production methods

In this preparation method, phenol and phosphorus trichloride was used as raw materials. After esterification and vacuum distillation, the product namely triphenyl phosphite can be obtained.
3C6H5OH + PCl3 [15~20 ℃] → (C3H5O) 3P + 3HCl
Specific process can be classified into batch and continuous processes.
 (1) Batch process
The phenol was added into the reactor, after warming to melt phosphorus trichloride was added to react with phenol at 70~90 ℃. After the phosphorus trichloride addition was completed, the temperature of reaction mixture was raised to about 150 ℃. After the removal of hydrogen chloride and unreacted phenol dissolved under reduced pressure at a high temperature, the product can be achieved.
(2) The use of a tower reactor
Phenol was feeding under the condenser located in the upper portion of the tower, while phosphorus trichloride enters above the receptacle located in the lower portion of the tower. Both reacted in the tower, and the product was collected in the receiver, meanwhile by-product hydrogen chloride was introduced into the absorber tower via the upper end of the condenser. After some process of the crude ester such as distillation, the product can be obtained.

Chemical Properties

Triphenylphosphine is a white to light tan flaked solid. Insoluble inwater; slightly soluble in alcohol; soluble in benzene, acetone, carbon tetrachloride. Combustible.


Triphenylphosphine is used in the synthesis of Chlorambucil with cytotoxicity in breast and pancreatic cancers. Also used in the preparation of α-Tocopherol analogues for monitoring antioxidant status.

Production Methods

Triphenylphosphine is one of the most widely used phosphorus-containing reagents in organic synthesis for many types of transformations such as the Mitsunobu, the Wittig, and the Staudinger reaction. Triphenylphosphine can be prepared in the laboratory by treatment of phosphorus trichloride with phenylmagnesium bromide or phenyllithium. The industrial synthesis involves the reaction between phosphorus trichloride, chlorobenzene, and sodium.
PCl3 + 3 PhCl + 6 Na → PPh3 + 6 NaCl


ChEBI: Triphenylphosphine is a member of the class of tertiary phosphines that is phosphane in which the three hydrogens are replaced by phenyl groups. It has a role as a reducing agent. It is a member of benzenes and a tertiary phosphine.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 625, 1994 DOI: 10.1016/S0040-4039(00)75855-2

General Description

Rhodium and triphenylphosphine catalyst system has been used for the hydroformylation of soybean, safflower and linseed oils and their methyl esters. Polymer supported triphenylphosphine has been reported to efficiently catalyze the γ-addition of pronucleophiles to alkynoate. Triphenylphosphine reacts with hydrated ruthenium trichloride in methanol to afford [RuCl2(PPh3)4], [RuCl2(PPh3)3] and [RuCl3(PPh3)2CH3OH]. It participates in the Heck reaction of 4-bromoanisole and ethyl acrylate in ionic liquids.

Reactivity Profile

Triphenylphosphine reacts vigorously with oxidizing materials. .

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic; when heated to decomposition, emits highly toxic fumes of phosphine and POx.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion. Mildly toxic by inhalation. A skin and eye irritant. Combustible when exposed to heat or flame. Slight explosion hazard in the form of vapor when exposed to flame. Can react vigorously with oxidizing materials. To fight fire, use dry chemical, fog, CO2. When heated to decomposition it emits highly toxic fumes of phosphne and POx. See also PHOSPHINE and PHENOL.

Purification Methods

It crystallises from hexane, MeOH, diethyl ether, CH2Cl2/hexane or 95% EtOH. Dry it at 65o/<1mm over CaSO4 or P2O5. Chromatograph it through alumina using (4:1) *benzene/CHCl3 as eluent. [Blau & Espenson et al. J Am Chem Soc 108 1962 1986, Buchanan et al. J Am Chem Soc 108 1537 1986, Randolph & Wrighton J Am Chem Soc 108 3366 1986, Asali et al. J Am Chem Soc 109 5386 1987.] It has also been crystallised twice from pet ether and 5 times from Et2O/EtOH to give m 80.5o. Alternatively, dissolve it in conc HCl, and upon dilution with H2O it separates because it is weakly basic, it is then crystallised from EtOH/Et2O. It recrystallises unchanged from AcOH. [Forward et al. J Chem Soc Suppl. p121 1949, Muller et al. J Am Chem Soc 78 3557 1956.] 3Ph3P.4HCl crystallises out when HCl gas is bubbled through an Et2O solution, it has m 70-73o, but recrystallises very slowly and is deliquescent. The hydriodide, made by adding Ph3P to hydriodic acid, is not hygroscopic and decomposes at ~100o. The chlorate (1:1) salt has m 165-167o, but decomposes slowly at 100o. All salts hydrolyse in H2O to give Ph3P [IR, UV: Sheldon & Tyree J Am Chem Soc 80 2117 1958, pK: Henderson & Streuli J Am Chem Soc 82 5791 1960, Kosolapoff, Organophosphorus Compounds, Wiley 1950]. [Beilstein 16 IV 951.] § Available commercially on a polystyrene or polyethyleneglycol support.

Synthesis of Triphenylphosphine from Phenol
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Triphenylphosphine pictures 2023-11-29 Triphenylphosphine
US $0.00 / Kg/Drum 1KG 99% 2000mt Jinan Finer Chemical Co., Ltd
Triphenylphosphine pictures 2023-10-07 Triphenylphosphine
US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
Triphenylphosphine pictures 2023-09-14 Triphenylphosphine
US $0.00-0.00 / kg 1kg 99% 20MT Wuhan Han Sheng New Material Technology Co.,Ltd
  • Triphenylphosphine pictures
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