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(S)-(+)-2-Amino-3-methyl-1-butanol

(S)-(+)-2-Amino-3-methyl-1-butanol structure

CAS No.: 2026-48-4

Chemical Name:: (S)-(+)-2-Amino-3-methyl-1-butanol

Synonyms: L-VALINOL;L-VALINAL;S-VALINOL;H-VAL-OL;l-2-amino-3-methylbutan-1-ol;L-2-AMINO-3-METHYL-1-BUTANOL;(S)-2-AMINO-3-METHYL-1-BUTANOL;M0;val-ol;L-Valino

CBNumber:: CB9319657

Molecular Formula:: C5H13NO

Molecular Weight:: 103.16

MDL Number:: MFCD00064296

MOL File:: 2026-48-4.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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(S)-(+)-2-Amino-3-methyl-1-butanol Properties

Melting point	30-34 °C
Boiling point	81 °C8 mm Hg(lit.)
alpha	16 º (c=10,EtOH)
Density	0.926 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4548(lit.)
Flash point	196 °F
storage temp.	Store at +2°C to +8°C.
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.82±0.10(Predicted)
form	Liquid After Melting
color	Clear slightly yellow
optical activity	[α]25/D +10°, c = 10 in H2O
Water Solubility	Soluble in water.
Sensitive	Air Sensitive
BRN	1719137
InChIKey	NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference	2026-48-4(CAS DataBase Reference)
FDA UNII	R54N4NJ3ZZ
NIST Chemistry Reference	(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313

Hazard Codes

Risk Statements

36-36/37/38

Safety Statements

26-24/25-36

WGK Germany

10-23

HazardClass

IRRITANT

HS Code

29221980

NFPA 704

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(S)-(+)-2-Amino-3-methyl-1-butanol price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	186708	(S)-(+)-2-Amino-3-methyl-1-butanol 96%	2026-48-4	1g	$52.2	2023-06-20	Buy
Sigma-Aldrich	186708	(S)-(+)-2-Amino-3-methyl-1-butanol 96%	2026-48-4	5g	$84.6	2023-06-20	Buy
Sigma-Aldrich	8.14082	(S)-(+)-2-Amino-3-methyl-1-butanol for synthesis	2026-48-4	1mL	$11.6	2023-06-20	Buy
TCI Chemical	V0058	L-Valinol >97.0%(GC)(T)	2026-48-4	5g	$104	2023-06-20	Buy
TCI Chemical	V0058	L-Valinol >97.0%(GC)(T)	2026-48-4	25g	$312	2023-06-20	Buy

Product number	Packaging	Price	Buy
186708	1g	$52.2	Buy
186708	5g	$84.6	Buy
8.14082	1mL	$11.6	Buy
V0058	5g	$104	Buy
V0058	25g	$312	Buy

(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.

Uses

(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:

Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

(S)-(+)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

(4S 4'S)-(-)-2 2'-(3-PENTYLIDENE)BIS(4-& (S)-4,5-DIHYDRO-2-(2-((S)-4,5-DIHYDRO-4-ISOPROPYLOXAZOL-2-YL)PROPAN-2-YL)-4-ISOPROPYLOXAZOLE (S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone (S,S)-2,6-BIS(4-ISOPROPYL-2-OXAZOLIN-2-YL)PYRIDINE 1-[(4S)-4-(1-Methylethyl)-2-thioxo-3-oxazolidinyl]-

Carbamic acid, [(1R)-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester (9CI) 5-isopropylmorpholin-3-one CYCLO(-VAL-VAL) (S)-4-(1-Isopropyl)-3-(1-oxobutyl)-2-oxazolidinone (S)-1-Methoxymethyl-2-methyl-propylamine

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(S)-(+)-2-Amino-3-methyl-1-butanol Suppliers

Global( 484)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan DaKen Chemical CO.,LTD.	+86-0371-66670886	info@dakenchem.com	China	14736	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21722	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	fandachem@gmail.com	China	9365	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32237	60
Zjartschem	+86-571-8723 8903 jocelynpan@zjarts.com	jocelynpan@zjarts.com	CHINA	993	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29922	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28183	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2973	58

Supplier	Advantage
Henan DaKen Chemical CO.,LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from (S)-(+)-2-Amino-3-methyl-1-butanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-07-26	(S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2022-10-11	(S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	(S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4	US $20.00 / KG	25KG	98%	100kg	Career Henan Chemical Co

(S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

(S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

(S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $20.00 / KG
98%
Career Henan Chemical Co

(S)-(+)-2-Amino-3-methyl-1-butanol Spectrum

(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)MS (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)¹HNMR (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)¹³CNMR (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)IR1 (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)Raman

2026-48-4((S)-(+)-2-Amino-3-methyl-1-butanol)Related Search:

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L-VALINAL (+)-L-VALINOL L-(+)-VALINOL L-VALINOL L-2-AMINO-3-METHYL-1-BUTANOL l-2-amino-3-methylbutan-1-ol H-VALINOL H-VAL-OL H-L-VAL-OL (2S)-2-AMINO-3-METHYL-BUTAN-1-OL L-Valinol ,98% (S)-2-Isopropyl-2-aminoethanol (S)-(+)-2-Amino-3-methyl-1-butanol,96% L-Valinol ,98% [ee: 95%] L-Valinol ,95% (S)-(+)-2-Amino-3-me L-Valino (S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S (S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal) L-Valinol, 98%, ee: 95% PKC PharMaceuticals, Inc. L - valerian aMMonia alcohol L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol (S)-(+)-2-Amino-3-methyl-1-butanol 96% L-Valinol Free Base L-Valinol, ee: 95% L-Valinol≥ 98% (GC) L-Valinol,99%e.e. L-Valinol,Elvitegravir intermediate 1-Butanol, 2-amino-3-methyl-, (S)- (S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol Valinol,97% (R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol L-Valanol (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC) L-Val-ol (S)-2-AMINO-3-METHYL-1-BUTANOL 98.0% 1-Butanol, 2-amino-3-methyl-, (2S)- S-VALINOL (S)-2-AMINO-3-METHYL-L-BUTANOL (S)-(+)-2-AMINO-3-METHYL-BUTANOL (S)-2-AMINO-3-METHYL-BUTAN-1-OL (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL (S)-2-AMINO-3-METHYL-1-BUTANOL S-(-)-2-AMINO-3-METHYL-1-BUTANOL H-Val-ol (S)-(+)-2-Amino-3-methyl-1-butanol) -(+)-VaL (S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP M0 AMG-232-008 (+)-Valinol val-ol 2026-48-4 2046-48-4 226-48-4 AMINE